metamorphosis
Doxepin at low doses (5-10 mg), is basically a antihistamine without anticholinergic properties. Trazodone is -- involving cholinergic & histamine effects. That is the main thing I try to look for to work. I will take a histamine blocker that works without effects on acetylcholine anyday. The OTC Diphen. and doxylamine are +++ in their cholinergic effects. You have the ap/aap's. And you know they affect many NT's and areas of the brain. My pdoc had me try Saphris at 2.5 mg (low) for sleep-Never Again. I woke in a daze about halfway through the night and just started eating half awake. 3 times and that was it. This is why I remind myself to steer clear of ap/aap's. Except for Abilify which effects the brain in its own separate and unique way.