I started cipralex about 5 weeks ago for depression/anxiety and it started working on the depression on the 3rd week and it was just starting to kick in for the anxiety, but I wound up going out and drinking some and I've been smoking a lot of cigarettes lately because I've been out late and they make me feel safer when I'm walking alone. I've drank before on cipralex and felt very few negative effects from it, but after the cigarettes I just feel like I've undone all the work. I've been getting really down again lately and I feel awful! Obviously I'm going to stay away from cigarettes from now on, but I was wondering if anyone else had this problem or knows why cigarettes might have a depressant/anxiety-inducing effect?