I've been taking 25 mgs of Zoloft for my Panic Disorder for the past several months. I've noticed some symptoms that went away over time, but there are new ones now. For example, the first month or two, once I took my Zoloft, I was asleep a half hour later. No exceptions. It knocked me out. Now it doesn't do that. I do think it may affect my appetite a bit. I would blame it on my Adderall, but a lot of the time if I eat late and end up taking my Zoloft before my meal (I take my Zoloft at 8 PM) I'm not very hungry. My Adderall's definitely worn off before then. I've also been warned that SSRIs can increase feelings of depression. For the past several weeks I've been dealing with that. I've felt tired, hopeless, and lacked motivation. It's mostly a problem at night, which wouldn't be a problem if said hopelessness didn't make it hard to sleep, but there have been days it's bothered me during the day as well. There was one day where I couldn't force myself out of bed and I kept breaking down in tears periodically through the day. Has anyone else experienced this while taking Zoloft? Any advice?