**Elevated Serum Homocysteine Levels, ADHD, Autism Spectrum Disorder, Hypermobile joints (often also have flat feet, pectus excavatum/carinatum), "Fibromyalgia" (I hate this diagnosis name but basically unexplained pain issues) Hashimoto's thyroiditis, IBS / Inflammatory GI issues, Queerness (gender or sexual orientation), migraine headache (mostly XX humans). Non-gender normative behavior, Congenital Adrenal Hyperplasia (hormonal disruption, hirsutism, or passing out when standing up / "POTS", high resting heart rate, poor stress tolerance), PTSD, Bipolar/Schizo/depression (burnout type), Generalized Anxiety, Eczema, Severe acne in natal females (PCOS), Mast Cell Issues / Allergies, Myopia (negative glasses prescription), Increased Intelligence, Genetic mutations in MTHFR or MTR/R, Irritable Bladder or IC (acidic urine typically, gets up a lot at night to urinate), Spider veins (especially at the base of the neck posteriorly/upper back as well as "cherry hemangiomas". "Translucent" skin with easily visible vasculature.
In cis MPS-MPS relationships, You will often see a masculine woman paired with a feminine man. In trans relationships, it's basically the same thing, a feminine person with a masculine person. We theorize this is to offset the hormonal imbalance issues and is therefore more likely to be a successful pregnancy.
In terms of body habitus, the skinny low muscular ones tend to look like LOTR elves. They have high angular facial features and even somewhat look like a pointed ear. The lesbians that come out as transgender men that look like little pixies, they start on testosterone and suddenly become gay transgender men are this type 1 phenotype, the tall spindly 6'4 transgender woman with no muscle mass will have an absolutely enormous Adam's apple, and significantly above average length penis is the same variant but in MTF.
The stocky, thick, large breasted, big butted humans that look like they have a lot of cortisol circulating tend to look almost like dwarves from LOTR. Wider more round faces. This is a different subtype, and the lesbians that come out as FTM in this subtype remain attracted to women. Additionally they end up with better vocal development related to slowly transitioning on their own with elevated androgens throughout their life prior to starting full FTM HRT. The gay men of this subtype that have the elevated DHT end up having an early puberty, have a short, thicker penis, are short in height, Have male pattern baldness, and basically look like Burl Ives. They often have a very brassy voice that sounds similar in timbre to many transgender men who were started on testosterone too rapidly and end up ossifying their larynx before normbal vocal development can occur (which creates that brassy transgender man voice that makes them sound like a gay man). You can replicate this voice style by compressing your larynx while you speak and you'll understand what I mean.
Personality effects: Interest in fantasy worlds / gaming, "Nerd culture" (Star trek/wars/Dr who) Otakus/Anime, Ren Faire, Non-traditional relationship structures, BDSM interest. ( I think all of this personality stuff is related to these people being faintly dissociated all the time, often related to VDR/COMT/MAO mutations amplified by MTHFR defects.) Thus, the idea of "other realities" is quite easy for their brains to accept, hence the interest in these common topics.
The exception of this is the autism, which I suspect is related to perinatal estradiol levels which are effectively driven by maternal reactions to heavy folate supplementation in prenatal vitamins affecting women with MTHFR deficiencies different than other cisgender women. In short, the reason for autism is the same reason for being transgender but they are not directly genetically linked. They are both an effect caused by underlying hormonal enzyme mutations or perinatal hormonal disruption.
See my recent post on this which is my theory of why autism has become so prevalent since 1991 and the direct association between autism and increasing perinatal folic acid use as well as the complete inverse proportionality between spina bifida rates and autism rates in the entire world.
Not everyone who has the syndrome will have all aspects of it. But many people have multiple things. I myself have many of the things and I also have the same genetic mutations in MTHFR and MTR/R but no gender issues. My dad has hashimoto's and aromatase excess and both parents gave me MTHFR variants.
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Nyctophilia
